Sample ID * TY (5864-575M)
Owner None
Strain Name(s) B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax; JR005864
Strain ID JR005864, MMRRC 34832-JAX
Sex female
Platform GigaMUGA
% Het. Calls 0.52%
% Hom. Calls 96.02%
% No Calls 3.47%
% Concordance N/A
Haplotype Candidate False
Notes: Two expression plasmids (Mo/HuAPP695swe and PS1-dE9) were designed to each be controlled by independent mouse prion protein (PrP) promoter elements, directing transgene expression predominantly to CNS neurons. The Mo/HuAPP695swe transgene expresses a "humanized" mouse amyloid beta (A4) precursor protein gene modified at three amino acids to reflect the human residues and further modified to contain the K595N/M596L (otherwise known as K670N/M671L) mutations linked to familial Alzheimers. The PS1-dE9 transgene expresses a mutant human presenilin 1 carrying the exon-9-deleted variant (PSEN1dE9) associated with familial Alzheimer's disease. These constructs were coinjected into B6C3HF2 pronuclei and insertion of the transgenes occured at a single locus. Founder line 85 was obtained and the resulting colony was maintained as a hemizygote by crossing transgenic mice to B6C3F1/J mice. Transgenic mice were then backcrossed to C57BL/6J for at least eight generations.

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Contributing Haplotype Strains:

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