|Sample ID*||TY (5864-575M)|
|Strain Name(s)||B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax; JR005864|
|Strain ID||JR005864, MMRRC 34832-JAX|
|% Het. Calls||0.52%|
|% Hom. Calls||96.02%|
|% No Calls||3.47%|
|Notes:||Two expression plasmids (Mo/HuAPP695swe and PS1-dE9) were designed to each be controlled by independent mouse prion protein (PrP) promoter elements, directing transgene expression predominantly to CNS neurons. The Mo/HuAPP695swe transgene expresses a "humanized" mouse amyloid beta (A4) precursor protein gene modified at three amino acids to reflect the human residues and further modified to contain the K595N/M596L (otherwise known as K670N/M671L) mutations linked to familial Alzheimers. The PS1-dE9 transgene expresses a mutant human presenilin 1 carrying the exon-9-deleted variant (PSEN1dE9) associated with familial Alzheimer's disease. These constructs were coinjected into B6C3HF2 pronuclei and insertion of the transgenes occured at a single locus. Founder line 85 was obtained and the resulting colony was maintained as a hemizygote by crossing transgenic mice to B6C3F1/J mice. Transgenic mice were then backcrossed to C57BL/6J for at least eight generations.|
Genome Karyotype Plot
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You can modify the "Contributing Haplotype Strains" below and click "Save Edits". This will cause the haplotype structure of this strain to be inferred based on these settings (using a hidden markov model) and rendered in a plot below.