Sample: TY
Sample ID | *TY (5864-575M) |
---|---|
Owner | None |
Strain Name(s) | B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax; JR005864 |
Strain ID | JR005864, MMRRC 34832-JAX |
Sex | female |
Platform | GigaMUGA |
% Het. Calls | 0.52% |
% Hom. Calls | 96.02% |
% No Calls | 3.47% |
% Concordance | N/A |
Haplotype Candidate | False |
Notes: | Two expression plasmids (Mo/HuAPP695swe and PS1-dE9) were designed to each be controlled by independent mouse prion protein (PrP) promoter elements, directing transgene expression predominantly to CNS neurons. The Mo/HuAPP695swe transgene expresses a "humanized" mouse amyloid beta (A4) precursor protein gene modified at three amino acids to reflect the human residues and further modified to contain the K595N/M596L (otherwise known as K670N/M671L) mutations linked to familial Alzheimers. The PS1-dE9 transgene expresses a mutant human presenilin 1 carrying the exon-9-deleted variant (PSEN1dE9) associated with familial Alzheimer's disease. These constructs were coinjected into B6C3HF2 pronuclei and insertion of the transgenes occured at a single locus. Founder line 85 was obtained and the resulting colony was maintained as a hemizygote by crossing transgenic mice to B6C3F1/J mice. Transgenic mice were then backcrossed to C57BL/6J for at least eight generations. |
Genome Karyotype Plot
Click any area of the karyotype plot to get a zoomed in view.
Contributing Haplotype Strains: